Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression.During steel-cockrings development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted embryonic cells into differentiated somatic cell lineages.Repressive histone mod
Production of fluent speech in humans is based on a precise and coordinated articulation of sounds.A speech articulation network (SAN) has been observed in multiple brain studies typically using either neuroimaging or direct electrical stimulation (DES), thus giving limited knowledge about the whole brain structural and functional organization of t
Abstract Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of COVID-19 patients all over the world.Clinical presentations range from asymptomatic, mild respiratory tract infection, to severe cases with acute respiratory distress syndrome, respiratory failure, and death.Reports on a dysregulated immune system in the sever
One of the key challenges when looking for the causes of a complex event is to determine the causal steel-cockrings status of factors that are neither individually necessary nor individually sufficient to produce that event.In order to reason about how such factors should be taken into account, we need a vocabulary to distinguish different cases.In